NME7

Across TCGA patient cohorts, NME7 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME7-associated genes across cancer lineages are NDRG1_pT346, A-Raf_pS299, and MEK1. Each is linked with NME7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME7-to-partner and partner-to-NME7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDRG1_pT346 grouped by NME7-low versus NME7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME7→partner) and Y-score (partner→NME7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDRG1_pT346 →	-0.529	-2.115	.013	.019	3	2
UCEC	A-Raf_pS299 →	-0.108	-3.169	.038	.019	3	1
UCEC	MEK1 →	+0.345	+2.115	.031	.019	3	1
UCEC	MIG-6 →	+0.092	+3.169	.033	.018	3	1
UCEC	p27_pT198 →	+0.134	+2.115	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.608	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

NDRG1_pT346 by NME7 expression — UCEC

Explore this box plot interactively →