NME6

Across TCGA patient cohorts, NME6 mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME6-associated genes across cancer lineages are TRBV16, RNA5SP412, and IGHV1OR21-1. Each is linked with NME6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME6-to-partner and partner-to-NME6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV16 grouped by NME6-low versus NME6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME6→partner) and Y-score (partner→NME6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRBV16 →	+0.444	+3.007	<.001	.001	3	1
UCEC	RNA5SP412 →	+0.876	+2.704	<.001	.004	3	1
UCEC	IGHV1OR21-1 →	+0.985	+2.800	<.001	.005	3	1
UCEC	GLYAT →	+0.109	+2.350	.003	.007	3	1
UCEC	FCRL3 →	+0.449	+3.332	.004	.005	3	1
UCEC	TRAT1 →	+0.504	+3.332	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

TRBV16 by NME6 expression — UCEC

Explore this box plot interactively →