NME6

Across TCGA patient cohorts, NME6 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME6-associated genes across cancer lineages are IGFBP2, AMPK_alpha, and ATM. Each is linked with NME6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME6-to-partner and partner-to-NME6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by NME6-low versus NME6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME6→partner) and Y-score (partner→NME6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.761	-3.000	.042	.037	3	1
UCEC	AMPK_alpha →	+0.269	+3.000	.014	.037	3	1
UCEC	ATM →	-0.531	-3.000	.042	.037	3	1
UCEC	Cyclin-B1 →	+0.680	+3.000	.036	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

IGFBP2 by NME6 expression — UCEC

Explore this box plot interactively →