NME6

Across TCGA cell cohorts, NME6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,780 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NME6-associated GO terms across cancer lineages are Pyrimidine ribonucleotide salvage, Pyrimidine nucleotide salvage, and Chemokine (C-C motif) ligand 21 signaling pathway. Each is linked with NME6 in more than 13 cancer types. Because this analysis shows association rather than direction, both NME6-to-partner and partner-to-NME6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pyrimidine ribonucleotide salvage grouped by NME6-low versus NME6-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME6→partner) and Y-score (partner→NME6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Pyrimidine ribonucleotide salvage →	+0.163	+0.703	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Pyrimidine nucleotide salvage →	+0.151	+0.777	.001	.005	3	12
URINARY_TRACT	Chemokine (C-C motif) ligand 21 signaling pathway →	+0.201	+0.708	<.001	.001	3	11
LARGE_INTESTINE	Pyrimidine-containing compound salvage →	+0.154	+0.532	<.001	<.001	2	10
BLOOD_Myeloma	Negative regulation of nuclear division →	+0.119	+0.856	.005	<.001	2	10
BONE	D-glucuronate catabolic process →	-0.249	-0.743	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,780 associations by consensus.

Pyrimidine ribonucleotide salvage by NME6 expression — CNS

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