NME5

Across TCGA patient cohorts, NME5 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME5-associated genes across cancer lineages are RNU6-821P, RNU6-789P, and COX6B1P6. Each is linked with NME5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME5-to-partner and partner-to-NME5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-821P grouped by NME5-low versus NME5-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME5→partner) and Y-score (partner→NME5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-821P →	+0.259	+4.497	<.001	.009	3	1
SKCM	RNU6-789P →	+0.399	+5.159	<.001	.007	3	1
SKCM	COX6B1P6 →	+0.210	+5.771	<.001	.003	3	1
SKCM	SRSF3P2 →	+0.117	+4.979	<.001	.009	3	1
SKCM	CDH12P1 →	+0.186	+6.199	<.001	.001	3	1
SKCM	MIR4296 →	+0.472	+4.979	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

RNU6-821P by NME5 expression — BLCA

Explore this box plot interactively →