NME5

Across TCGA cell cohorts, NME5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,119 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NME5-associated GO terms across cancer lineages are Intraciliary anterograde transport, Vacuolar acidification, and Lysosomal lumen acidification. Each is linked with NME5 in more than 7 cancer types. Because this analysis shows association rather than direction, both NME5-to-partner and partner-to-NME5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intraciliary anterograde transport grouped by NME5-low versus NME5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME5→partner) and Y-score (partner→NME5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Intraciliary anterograde transport →	+0.106	+1.316	<.001	<.001	3	8
CNS	Vacuolar acidification →	+0.047	+0.544	.009	.006	3	8
UPPER_AERODIGESTIVE_TRACT	Lysosomal lumen acidification →	+0.060	+0.089	.009	.008	3	8
SKIN	Vacuole organization →	+0.030	+0.798	<.001	<.001	3	7
SKIN	Regulation of smoothened signaling pathway →	+0.030	+0.743	.005	.002	3	7
LUNG_NSCLC_LUAD	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.043	-0.675	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,119 associations by consensus.

Intraciliary anterograde transport by NME5 expression — LUNG_SCLC

Explore this box plot interactively →