NME4

Across TCGA patient cohorts, NME4 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NME4-associated genes across cancer lineages are RN7SL869P, RNU6-487P, and OR4K3. Each is linked with NME4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NME4-to-partner and partner-to-NME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL869P grouped by NME4-low versus NME4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NME4→partner) and Y-score (partner→NME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL869P →	+0.139	+7.640	<.001	.009	3	2
UCEC	RNU6-487P →	+0.222	+3.399	.003	.005	3	2
UCEC	OR4K3 →	+0.061	+3.496	.001	.001	3	1
UCEC	DAZL →	+0.090	+4.401	.007	<.001	3	1
UCEC	RN7SL607P →	+0.406	+2.648	<.001	.006	3	1
UCEC	RN7SL386P →	+0.144	+3.014	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

RN7SL869P by NME4 expression — BLCA

Explore this box plot interactively →