NME4

Across TCGA cell cohorts, NME4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,442 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NME4-associated GO terms across cancer lineages are GTP biosynthetic process, Intermembrane phospholipid transfer, and Pyrimidine ribonucleoside triphosphate biosynthetic process. Each is linked with NME4 in more than 13 cancer types. Because this analysis shows association rather than direction, both NME4-to-partner and partner-to-NME4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTP biosynthetic process grouped by NME4-low versus NME4-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME4→partner) and Y-score (partner→NME4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GTP biosynthetic process →	+0.180	+1.666	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Intermembrane phospholipid transfer →	+0.160	+1.706	<.001	.001	3	13
LUNG_SCLC	Pyrimidine ribonucleoside triphosphate biosynthetic process →	+0.135	+2.436	<.001	<.001	3	12
LUNG_SCLC	CTP biosynthetic process →	+0.124	+2.274	.001	<.001	3	12
LUNG_SCLC	UTP biosynthetic process →	+0.181	+1.800	<.001	<.001	3	11
URINARY_TRACT	Pyrimidine nucleoside triphosphate metabolic process →	+0.091	+1.827	<.001	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,442 associations by consensus.

GTP biosynthetic process by NME4 expression — LUNG_SCLC

Explore this box plot interactively →