NME3

Across TCGA pan-cancer cohorts, NME3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NME3 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NME3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NME3 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and OV are the cancer types where NME3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.911	.012	24	view →
CCRCC	DFS	Tertile	II,III,IV	0.928	0.147	.020	9	view →
OV	DFS	Median	All	0.923	0.650	.029	8	view →
GBM	OS	Tertile	All	0.374	0.671	.006	8	view →
LSCC	DFS	Quartile	III,IV	0.332	0.894	.002	5	view →
PDAC	OS	Quartile	All	0.652	0.385	.017	5	view →
LUAD	OS	Median	All	0.963	0.792	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NME3–COAD (DFS)

Open the COAD breakdown →