NME2

Across TCGA cell cohorts, NME2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,842 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible NME2-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Response to topologically incorrect protein, and U4 snRNA 3'-end processing. Each is linked with NME2 in more than 12 cancer types. Because this analysis shows association rather than direction, both NME2-to-partner and partner-to-NME2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by NME2-low versus NME2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME2→partner) and Y-score (partner→NME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to endoplasmic reticulum stress →	-0.088	-0.953	<.001	<.001	3	13
URINARY_TRACT	Response to topologically incorrect protein →	-0.088	-0.912	.004	<.001	3	13
URINARY_TRACT	U4 snRNA 3'-end processing →	+0.136	+0.855	.003	.003	3	12
URINARY_TRACT	Cellular response to topologically incorrect protein →	-0.065	-0.544	.001	.003	3	12
PANCREAS	Succinate transport →	+0.280	+0.835	<.001	<.001	3	11
PANCREAS	Ribosome assembly →	+0.067	+0.796	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,842 associations by consensus.

Response to endoplasmic reticulum stress by NME2 expression — URINARY_TRACT

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