NME1

Across TCGA pan-cancer cohorts, NME1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NME1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NME1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NME1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUAD are the cancer types where NME1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.494	.016	32	view →
HNSC	OS	Quartile	IV	0.647	0.944	.011	19	view →
LUAD	OS	Median	II,III,IV	0.336	1.000	<.001	16	view →
GBM	DFS	Quartile	All	0.289	0.481	.010	10	view →
LSCC	DFS	Median	III,IV	0.358	0.854	.002	10	view →
CCRCC	OS	Tertile	II,III,IV	0.834	1.000	.029	9	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NME1–UCEC (OS)

Open the UCEC breakdown →