NME1

Across TCGA cell cohorts, NME1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,050 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NME1-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, Maturation of 5.8S rRNA, and Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with NME1 in more than 17 cancer types. Because this analysis shows association rather than direction, both NME1-to-partner and partner-to-NME1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by NME1-low versus NME1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME1→partner) and Y-score (partner→NME1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	-0.077	-0.979	.003	.003	3	18
LUNG_SCLC	Maturation of 5.8S rRNA →	+0.108	+1.004	<.001	<.001	3	17
URINARY_TRACT	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.164	+1.275	<.001	<.001	3	17
BONE	DNA replication initiation →	+0.189	+0.968	.003	.001	3	17
URINARY_TRACT	Response to topologically incorrect protein →	-0.099	-1.120	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Maturation of SSU-rRNA →	+0.150	+1.471	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,050 associations by consensus.

Response to endoplasmic reticulum stress by NME1 expression — BLOOD_Myeloma

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