Across TCGA pan-cancer cohorts, NMD3P1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NMD3P1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where NMD3P1 RNA is repressed in tumor relative to normal tissue. In most cancer types NMD3P1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, KICH, and BRCA are the cancer types where NMD3P1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NMD3P1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.