NMD3

Across TCGA pan-cancer cohorts, NMD3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NMD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NMD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NMD3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where NMD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NMD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.823	<.001	12	view →
COAD	Female	II,III,IV	+0.937	<.001	9	view →
KIRC	Female	All	+0.528	<.001	8	view →
READ	All	II,III,IV	+0.739	.002	6	view →
LUAD	Male	All	+0.598	<.001	6	view →
LUSC	Female	All	+0.850	<.001	5	view →
THCA	All	All	−0.296	<.001	4	view →
BRCA	All	II,III,IV	+0.230	.001	4	view →
CHOL	All	All	+0.629	.006	3	view →
KICH	All	All	−0.519	.014	2	view →
PAAD	Male	All	+0.464	.006	2	view →
STAD	All	II,III,IV	+0.368	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NMD3–HNSC

Open the HNSC breakdown →