NLRX1

Across TCGA pan-cancer cohorts, NLRX1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NLRX1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NLRX1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NLRX1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where NLRX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.769	0.509	<.001	72	view →
LUAD	DFS	Median	III,IV	0.619	0.867	.016	6	view →
CCRCC	DFS	Median	All	0.851	0.606	.034	4	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NLRX1–HNSC (DFS)

Open the HNSC breakdown →