NLRX1

Across TCGA patient cohorts, NLRX1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRX1-associated genes across cancer lineages are ATM, c-Kit, and FASN. Each is linked with NLRX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRX1-to-partner and partner-to-NLRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NLRX1-low versus NLRX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRX1→partner) and Y-score (partner→NLRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.448	-1.794	.001	.024	3	3
UCEC	c-Kit →	-0.150	-1.353	.040	.015	3	3
COAD	FASN →	+0.569	+2.815	.007	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.517	+2.824	<.001	.034	3	2
SKCM	p90 RSK →	+0.286	+3.000	.003	.035	3	2
UCEC	HER3 →	+0.222	+1.335	.010	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by NLRX1 expression — UCEC

Explore this box plot interactively →