NLRX1

Across TCGA cell cohorts, NLRX1 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRX1-associated genes across cancer lineages are F9, PDHA2, and FFAR3. Each is linked with NLRX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRX1-to-partner and partner-to-NLRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F9 grouped by NLRX1-low versus NLRX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRX1→partner) and Y-score (partner→NLRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	F9 →	+0.036	+5.643	<.001	.002	3	1
LUNG_SCLC	PDHA2 →	+0.033	+5.029	<.001	.006	3	1
LUNG_SCLC	FFAR3 →	+0.058	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SLC32A1 →	+0.630	+3.223	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.016	+3.744	<.001	.003	3	1
BLOOD_Leukemia	IL4 →	+2.076	+3.007	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

F9 by NLRX1 expression — LUNG_SCLC

Explore this box plot interactively →