NLRX1

Across TCGA cell cohorts, NLRX1 mutation is significantly associated with the mutation status of many other genes, with 4,008 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRX1-associated genes across cancer lineages are DENND5A, TRPM3, and ZBTB11. Each is linked with NLRX1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRX1-to-partner and partner-to-NLRX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DENND5A grouped by NLRX1-low versus NLRX1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRX1→partner) and Y-score (partner→NLRX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DENND5A →	+5.502	+5.502	.003	.003	1	5
LARGE_INTESTINE	TRPM3 →	+1.943	+3.413	<.001	<.001	1	5
OVARY	ZBTB11 →	+3.217	+3.684	.006	.006	1	4
CNS	ERCC6L2 →	+4.614	+4.614	.006	.006	1	4
CNS	MYT1 →	+5.614	+5.044	.003	.003	1	4
CNS	TNS1 →	+4.614	+4.614	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,008 associations by consensus.

DENND5A by NLRX1 expression — LUNG_SCLC

Explore this box plot interactively →