Across TCGA patient cohorts, NLRP9 mutation is significantly associated with the RNA expression of many other genes, with 3,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP9-associated genes across cancer lineages are KCTD9, CDCA2, and ENO1. Each is linked with NLRP9 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP9-to-partner and partner-to-NLRP9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP9→partner) and Y-score (partner→NLRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KCTD9 →	+0.547	+2.960	.005	<.001	3	5
COAD	CDCA2 →	+0.705	+3.605	<.001	.001	3	4
UCEC	ENO1 →	+0.376	+2.338	.006	<.001	3	4
COAD	PBK →	+0.858	+2.262	<.001	.005	3	4
UCEC	PELO →	+0.377	+2.706	<.001	<.001	3	4
MESO	SOD1P2 →	+0.127	+5.321	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

Exploration

NLRP9 survival (RNA) · tumor vs normal (RNA) · all NLRP9 data types