Across TCGA patient cohorts, NLRP9 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP9-associated genes across cancer lineages are Cyclin-B1, Caspase-7-cleavedD198, and ASNS. Each is linked with NLRP9 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP9-to-partner and partner-to-NLRP9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP9→partner) and Y-score (partner→NLRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.517	+2.321	.003	.005	3	5
COAD	Caspase-7-cleavedD198 →	+1.336	+2.467	<.001	.011	3	4
UCEC	ASNS →	+0.382	+1.502	<.001	.027	3	4
LUSC	Bap1-c-4 →	+0.219	+2.816	.030	.001	3	3
COAD	p70-S6K →	+0.245	+2.484	.028	.010	3	3
SKCM	p27_pT157 →	+0.090	+2.265	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

NLRP9 survival (RNA) · tumor vs normal (RNA) · all NLRP9 data types