Across TCGA cell cohorts, NLRP9 mutation is significantly associated with the RNA expression of many other genes, with 475 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP9-associated genes across cancer lineages are TVP23B, GHRHR, and OR4X2. Each is linked with NLRP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP9-to-partner and partner-to-NLRP9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP9→partner) and Y-score (partner→NLRP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TVP23B →	+0.764	+3.502	<.001	.001	3	2
BLOOD_Leukemia	GHRHR →	+0.290	+3.536	<.001	.001	3	2
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1
SOFT_TISSUE	IFNA14 →	+0.024	+4.369	<.001	.008	3	1
OESOPHAGUS	SRRM4 →	+0.083	+4.108	<.001	.005	3	1
OESOPHAGUS	CLDN17 →	+0.407	+3.392	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 475 associations by consensus.

Exploration

NLRP9 survival (RNA) · tumor vs normal (RNA) · all NLRP9 data types