NLRP7

Across TCGA patient cohorts, NLRP7 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP7-associated genes across cancer lineages are ATM, MYH11, and Cyclin-B1. Each is linked with NLRP7 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP7-to-partner and partner-to-NLRP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NLRP7-low versus NLRP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP7→partner) and Y-score (partner→NLRP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.509	-3.893	<.001	<.001	3	4
STAD	MYH11 →	-1.438	-3.321	.039	.010	3	3
UCEC	Cyclin-B1 →	+0.683	+1.893	<.001	<.001	3	3
SKCM	c-Kit →	-0.402	-1.415	.027	.041	3	3
COAD	FASN →	+0.509	+1.882	.001	.031	3	3
COAD	Caspase-7-cleavedD198 →	+0.989	+1.882	.002	.031	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

ATM by NLRP7 expression — UCEC

Explore this box plot interactively →