NLRP7

Across TCGA cell cohorts, NLRP7 mutation is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP7-associated genes across cancer lineages are CST9, FAM86B1, and CFAP97D2. Each is linked with NLRP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP7-to-partner and partner-to-NLRP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CST9 grouped by NLRP7-low versus NLRP7-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP7→partner) and Y-score (partner→NLRP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CST9 →	+0.018	+3.584	<.001	.003	3	2
LARGE_INTESTINE	FAM86B1 →	+1.165	+3.364	<.001	.002	3	2
LUNG_NSCLC_LUSC	CFAP97D2 →	+0.020	+4.643	<.001	.008	3	1
BLOOD_Leukemia	PHOX2B →	+0.016	+3.365	<.001	.005	3	1
BLOOD_Leukemia	OR7C2 →	+0.011	+4.247	<.001	.004	3	1
BLOOD_Leukemia	C1QL2 →	+0.009	+3.507	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

CST9 by NLRP7 expression — LUNG_SCLC

Explore this box plot interactively →