NLRP6

Across TCGA patient cohorts, NLRP6 protein abundance is significantly associated with the RNA expression of many other genes, with 239 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible NLRP6-associated genes across cancer lineages are GRK3, BRS3, and AP3B2. Each is linked with NLRP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP6-to-partner and partner-to-NLRP6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLRP6 versus GRK3 in PDAC, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP6→partner) and Y-score (partner→NLRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	GRK3 →	-0.377	-0.771	.001	<.001	3	1
PDAC	BRS3 →	-0.692	-0.915	.001	.001	3	1
PDAC	AP3B2 →	-0.414	-0.685	<.001	.001	3	1
PDAC	TBC1D17 →	-0.391	-0.598	.002	.007	3	1
PDAC	PIK3R2 →	-0.090	-1.051	.001	<.001	3	1
PDAC	FBXW4 →	-0.341	-0.819	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 239 associations by consensus.

NLRP6 vs GRK3 — PDAC

Explore this scatter interactively →