NLRP6

Across TCGA patient cohorts, NLRP6 mutation is significantly associated with the RNA expression of many other genes, with 2,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP6-associated genes across cancer lineages are RPL12P18, MIR1913, and RNU5A-4P. Each is linked with NLRP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP6-to-partner and partner-to-NLRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P18 grouped by NLRP6-low versus NLRP6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP6→partner) and Y-score (partner→NLRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL12P18 →	+0.135	+3.240	.005	.009	3	2
COAD	MIR1913 →	+0.319	+4.101	<.001	.001	3	2
CESC	RNU5A-4P →	+0.345	+3.934	<.001	.005	3	2
LUSC	ARL6IP1P3 →	+0.119	+4.165	.008	.001	3	2
LIHC	RN7SKP50 →	+0.102	+4.853	<.001	<.001	3	2
LUAD	ZP4 →	+0.343	+3.572	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,160 associations by consensus.

RPL12P18 by NLRP6 expression — HNSC

Explore this box plot interactively →