NLRP6

Across TCGA patient cohorts, NLRP6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP6-associated genes across cancer lineages are PDCD4, INPP4B, and PCNA. Each is linked with NLRP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP6-to-partner and partner-to-NLRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NLRP6-low versus NLRP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP6→partner) and Y-score (partner→NLRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.603	-2.459	.007	.020	3	2
UCEC	INPP4B →	-0.341	-2.999	.029	.035	3	1
UCEC	PCNA →	+0.276	+3.000	.008	.036	2	2
UCEC	Annexin-1 →	+0.586	+2.459	.021	.020	3	1
UCEC	STAT3_pY705 →	-0.458	-2.459	<.001	.020	3	1
UCEC	VHL →	-1.438	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PDCD4 by NLRP6 expression — UCEC

Explore this box plot interactively →