NLRP6

Across TCGA cell cohorts, NLRP6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,034 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLRP6-associated GO terms across cancer lineages are Regulation of DNA repair, Plasmacytoid dendritic cell activation, and Cell fate commitment. Each is linked with NLRP6 in more than 5 cancer types. Because this analysis shows association rather than direction, both NLRP6-to-partner and partner-to-NLRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA repair grouped by NLRP6-low versus NLRP6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP6→partner) and Y-score (partner→NLRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of DNA repair →	+0.076	+0.037	<.001	.009	3	6
OESOPHAGUS	Plasmacytoid dendritic cell activation →	-0.152	-0.181	.004	.009	3	6
BLOOD_Leukemia	Cell fate commitment →	-0.074	-0.548	<.001	<.001	3	6
SKIN	Purine nucleoside triphosphate biosynthetic process →	+0.097	+0.043	<.001	<.001	3	6
SKIN	Ribonucleoside triphosphate biosynthetic process →	+0.052	+0.030	.005	.006	3	6
SKIN	Purine ribonucleoside triphosphate biosynthetic process →	+0.097	+0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,034 associations by consensus.

Regulation of DNA repair by NLRP6 expression — LIVER

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