NLRP6

Across TCGA cell cohorts, NLRP6 mutation is significantly associated with the RNA expression of many other genes, with 186 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLRP6-associated genes across cancer lineages are IL36A, FGF23, and IL9. Each is linked with NLRP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP6-to-partner and partner-to-NLRP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by NLRP6-low versus NLRP6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP6→partner) and Y-score (partner→NLRP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL36A →	+0.739	+2.436	<.001	.006	3	2
URINARY_TRACT	FGF23 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	IL9 →	+0.130	+5.087	<.001	.004	3	1
URINARY_TRACT	SPPL2C →	+0.006	+5.087	<.001	.004	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
OVARY	CBLL2 →	+0.036	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

IL36A by NLRP6 expression — BLOOD_Leukemia

Explore this box plot interactively →