NLRP5

Across TCGA cell cohorts, NLRP5 RNA expression is significantly associated with the go_rna of many other GO terms, with 357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP5-associated GO terms across cancer lineages are Spliceosomal tri-snRNP complex assembly, Transcription initiation at RNA polymerase II promoter, and Regulation of nucleobase-containing compound transport. Each is linked with NLRP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP5-to-partner and partner-to-NLRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal tri-snRNP complex assembly grouped by NLRP5-low versus NLRP5-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP5→partner) and Y-score (partner→NLRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Spliceosomal tri-snRNP complex assembly →	+0.048	+0.023	.007	.005	3	4
SKIN	Transcription initiation at RNA polymerase II promoter →	+0.053	+0.035	<.001	.008	3	4
PANCREAS	Regulation of nucleobase-containing compound transport →	+0.069	+0.004	.007	.002	3	3
PANCREAS	Regulation of RNA export from nucleus →	+0.069	+0.004	.009	.002	3	3
LARGE_INTESTINE	Negative regulation of cilium assembly →	+0.030	+0.033	.008	.009	3	3
LARGE_INTESTINE	Cellular response to glucose starvation →	+0.031	+0.023	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 357 associations by consensus.

Spliceosomal tri-snRNP complex assembly by NLRP5 expression — LARGE_INTESTINE

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