NLRP5

Across TCGA cell cohorts, NLRP5 mutation is significantly associated with the RNA expression of many other genes, with 759 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP5-associated genes across cancer lineages are SAMD3, LAIR2, and ARSA. Each is linked with NLRP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP5-to-partner and partner-to-NLRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMD3 grouped by NLRP5-low versus NLRP5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP5→partner) and Y-score (partner→NLRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SAMD3 →	+0.762	+2.914	.005	.001	3	2
SKIN	LAIR2 →	+0.091	+2.288	<.001	.002	3	2
LARGE_INTESTINE	ARSA →	+0.551	+1.850	.005	.006	3	2
LARGE_INTESTINE	RRP9 →	+0.381	+1.850	.007	.006	3	2
LARGE_INTESTINE	TTI2 →	+0.517	+2.364	.003	<.001	3	2
LARGE_INTESTINE	STRA6 →	-1.250	-2.278	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 759 associations by consensus.

SAMD3 by NLRP5 expression — LUNG_SCLC

Explore this box plot interactively →