NLRP5

Across TCGA cell cohorts, NLRP5 mutation is significantly associated with the mutation status of many other genes, with 4,395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP5-associated genes across cancer lineages are MROH2B, SDK1, and ABCB5. Each is linked with NLRP5 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP5-to-partner and partner-to-NLRP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MROH2B grouped by NLRP5-low versus NLRP5-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP5→partner) and Y-score (partner→NLRP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MROH2B →	+1.794	+2.003	.006	.006	1	5
LARGE_INTESTINE	SDK1 →	+1.392	+2.656	<.001	<.001	1	5
SOFT_TISSUE	ABCB5 →	+4.066	+5.022	.001	.001	1	5
SOFT_TISSUE	CSMD1 →	+3.066	+4.369	.005	.005	1	5
LUNG_SCLC	PCDHA5 →	+3.157	+2.267	.008	.008	1	5
OVARY	POM121 →	+2.824	+4.347	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,395 associations by consensus.

MROH2B by NLRP5 expression — LUNG_SCLC

Explore this box plot interactively →