NLRP4

Across TCGA pan-cancer cohorts, NLRP4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NLRP4 data layer compared with 20 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NLRP4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NLRP4 expression acts as an unfavorable survival marker.

PDAC and CCRCC are the cancer types where NLRP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.155	0.768	.001	42	view →
CCRCC	DFS	Median	III,IV	0.208	0.932	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NLRP4–PDAC (DFS)

Open the PDAC breakdown →