NLRP2

Across TCGA pan-cancer cohorts, NLRP2 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NLRP2 data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NLRP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP2 expression acts as an unfavorable survival marker.

LSCC and LUAD are the cancer types where NLRP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.798	0.998	.007	13	view →
LUAD	DFS	Quartile	III,IV	0.409	0.881	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NLRP2–LSCC (OS)

Open the LSCC breakdown →