NLRP14

Across TCGA patient cohorts, NLRP14 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP14-associated genes across cancer lineages are FoxM1, Cyclin-B1, and ASNS. Each is linked with NLRP14 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP14-to-partner and partner-to-NLRP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NLRP14-low versus NLRP14-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP14→partner) and Y-score (partner→NLRP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.267	+3.355	.005	.004	3	5
UCEC	Cyclin-B1 →	+0.703	+3.247	<.001	<.001	3	4
UCEC	ASNS →	+0.418	+2.321	<.001	<.001	3	4
UCEC	ATM →	-0.480	-1.986	<.001	.008	3	4
UCEC	PCNA →	+0.216	+2.415	<.001	.002	3	3
LUAD	TSC1 →	-0.390	-1.584	.002	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

FoxM1 by NLRP14 expression — LUAD

Explore this box plot interactively →