NLRP14

Across TCGA cell cohorts, NLRP14 mutation is significantly associated with the RNA expression of many other genes, with 254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP14-associated genes across cancer lineages are BCL7A, C4orf17, and RTP1. Each is linked with NLRP14 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP14-to-partner and partner-to-NLRP14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL7A grouped by NLRP14-low versus NLRP14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP14→partner) and Y-score (partner→NLRP14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCL7A →	+0.722	+3.169	.003	.009	3	2
OESOPHAGUS	C4orf17 →	+0.096	+3.874	<.001	.003	3	1
OESOPHAGUS	RTP1 →	+0.019	+3.115	<.001	.005	3	1
OESOPHAGUS	KRTAP19-1 →	+0.677	+3.115	.001	.005	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	HSCB →	+0.514	+3.169	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 254 associations by consensus.

BCL7A by NLRP14 expression — LARGE_INTESTINE

Explore this box plot interactively →