NLRP12

Across TCGA pan-cancer cohorts, NLRP12 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated NLRP12 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher NLRP12 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP12 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, ACC, and LUSC are the cancer types where NLRP12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.135	0.888	<.001	48	view →
ACC	DFS	Median	All	0.120	0.772	<.001	30	view →
LUSC	DFS	Median	III,IV	0.179	0.662	.007	27	view →
UCEC	DFS	Median	II,III,IV	0.933	0.431	.012	24	view →
READ	DFS	Median	All	0.398	0.809	<.001	15	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	15	view →
COAD	OS	Median	III,IV	0.163	0.791	.004	11	view →
PAAD	OS	Median	All	0.117	0.640	.007	9	view →
SKCM	DFS	Median	IV	0.046	0.502	<.001	7	view →
PRAD	DFS	Median	All	0.617	0.886	.015	6	view →
BLCA	OS	Median	All	0.188	0.687	.020	6	view →
SARC	DFS	Median	All	0.065	0.632	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

NLRP12–THYM (OS)

Open the THYM breakdown →