NLRP12

Across TCGA patient cohorts, NLRP12 mutation is significantly associated with the RNA expression of many other genes, with 6,780 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP12-associated genes across cancer lineages are RPAIN, PARP2, and TLE6. Each is linked with NLRP12 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP12-to-partner and partner-to-NLRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPAIN grouped by NLRP12-low versus NLRP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP12→partner) and Y-score (partner→NLRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPAIN →	+0.395	+1.534	<.001	<.001	3	5
UCEC	PARP2 →	+0.521	+2.736	<.001	<.001	3	5
UCEC	TLE6 →	+0.528	+1.365	.001	.001	3	5
HNSC	ZNF77 →	+0.448	+2.610	.003	.005	3	5
HNSC	EEF1AKMT2 →	+0.299	+3.476	.006	.002	3	5
UCEC	FCER1A →	-0.628	-2.085	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,780 associations by consensus.

RPAIN by NLRP12 expression — UCEC

Explore this box plot interactively →