NLRP12

Across TCGA cell cohorts, NLRP12 mutation is significantly associated with the mutation status of many other genes, with 4,048 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP12-associated genes across cancer lineages are LYST, LRFN1, and MYO16. Each is linked with NLRP12 in more than 5 cancer types. Because this analysis shows association rather than direction, both NLRP12-to-partner and partner-to-NLRP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYST grouped by NLRP12-low versus NLRP12-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP12→partner) and Y-score (partner→NLRP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LYST →	+3.400	+4.784	<.001	<.001	1	6
SKIN	LRFN1 →	+3.718	+3.053	.006	.006	1	6
OVARY	MYO16 →	+3.632	+3.930	.003	.003	1	6
LARGE_INTESTINE	ARHGAP30 →	+1.584	+1.584	.009	.009	1	6
BLOOD_Leukemia	NES →	+3.025	+2.855	.003	.003	1	6
BLOOD_Lymphoma	DOCK3 →	+2.409	+3.033	.006	.006	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,048 associations by consensus.

LYST by NLRP12 expression — SOFT_TISSUE

Explore this box plot interactively →