NLRP11

Across TCGA patient cohorts, NLRP11 mutation is significantly associated with the RNA expression of many other genes, with 6,933 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP11-associated genes across cancer lineages are BCCIP, NEK2, and KIF11. Each is linked with NLRP11 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP11-to-partner and partner-to-NLRP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by NLRP11-low versus NLRP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP11→partner) and Y-score (partner→NLRP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BCCIP →	+0.389	+2.715	<.001	<.001	3	4
SKCM	NEK2 →	+0.369	+1.424	.006	.001	3	4
UCEC	KIF11 →	+0.762	+2.502	<.001	<.001	3	4
LUAD	TLK2 →	+0.314	+3.503	.003	.002	3	4
LUAD	DESI2 →	+0.414	+2.047	.001	.005	3	4
UCEC	LIN52 →	+0.370	+1.546	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,933 associations by consensus.

BCCIP by NLRP11 expression — UCEC

Explore this box plot interactively →