NLRP11

Across TCGA patient cohorts, NLRP11 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP11-associated genes across cancer lineages are HER2_pY1248, SLC1A5, and Cyclin-B1. Each is linked with NLRP11 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRP11-to-partner and partner-to-NLRP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by NLRP11-low versus NLRP11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP11→partner) and Y-score (partner→NLRP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.081	-1.550	.026	<.001	3	3
SKCM	SLC1A5 →	+0.225	+1.792	.028	<.001	3	3
UCEC	Cyclin-B1 →	+0.704	+2.169	<.001	<.001	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.330	+1.331	.036	.043	3	3
UCEC	Ku80 →	+0.254	+1.906	<.001	<.001	3	3
UCEC	mTOR_pS2448 →	-0.172	-1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

HER2_pY1248 by NLRP11 expression — SKCM

Explore this box plot interactively →