NLRP11

Across TCGA cell cohorts, NLRP11 mutation is significantly associated with the RNA expression of many other genes, with 213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP11-associated genes across cancer lineages are SLC25A35, NLRP14, and CTC1. Each is linked with NLRP11 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP11-to-partner and partner-to-NLRP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC25A35 grouped by NLRP11-low versus NLRP11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP11→partner) and Y-score (partner→NLRP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC25A35 →	+0.678	+3.237	.003	.003	3	2
LARGE_INTESTINE	NLRP14 →	+0.075	+3.304	.005	.008	3	2
LARGE_INTESTINE	CTC1 →	+0.752	+2.628	.002	.002	3	2
LUNG_SCLC	GAGE2E →	+2.220	+3.621	.004	.005	3	2
BLOOD_Myeloma	RBP3 →	+0.006	+4.807	<.001	.006	3	1
SKIN	MINAR2 →	+0.005	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 213 associations by consensus.

SLC25A35 by NLRP11 expression — LARGE_INTESTINE

Explore this box plot interactively →