NLRP10

Across TCGA patient cohorts, NLRP10 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP10-associated genes across cancer lineages are FoxM1, eIF4E, and Bap1-c-4. Each is linked with NLRP10 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP10-to-partner and partner-to-NLRP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NLRP10-low versus NLRP10-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP10→partner) and Y-score (partner→NLRP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.369	+2.825	.008	.033	3	4
UCEC	eIF4E →	+0.180	+2.000	.008	<.001	3	4
LUAD	Bap1-c-4 →	+0.264	+3.016	<.001	<.001	3	3
LUAD	Cyclin-B1 →	+0.806	+2.807	<.001	.003	3	3
UCEC	Notch1 →	+0.163	+2.428	<.001	.001	3	3
UCEC	ATM →	-0.561	-2.087	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

FoxM1 by NLRP10 expression — LUSC

Explore this box plot interactively →