NLRP10

Across TCGA cell cohorts, NLRP10 mutation is significantly associated with the RNA expression of many other genes, with 69 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NLRP10-associated genes across cancer lineages are MMP26, SEMG1, and TMSB4Y. Each is linked with NLRP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP10-to-partner and partner-to-NLRP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP26 grouped by NLRP10-low versus NLRP10-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP10→partner) and Y-score (partner→NLRP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MMP26 →	+0.156	+4.643	<.001	.008	3	1
CNS	SEMG1 →	+0.017	+3.302	<.001	.003	3	1
LARGE_INTESTINE	TMSB4Y →	+1.345	+3.556	<.001	.007	3	1
LARGE_INTESTINE	ARMS2 →	+0.183	+3.260	<.001	.002	3	1
STOMACH	CLEC4M →	+0.130	+3.044	<.001	.008	3	1
STOMACH	HS3ST2 →	+0.039	+4.050	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

MMP26 by NLRP10 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →