NLRP1

Across TCGA pan-cancer cohorts, NLRP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NLRP1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NLRP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NLRP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where NLRP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.398	0.888	.001	57	view →
LUAD	DFS	Median	All	0.791	0.417	<.001	36	view →
HNSC	DFS	Median	All	0.505	0.758	.002	7	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NLRP1–LSCC (DFS)

Open the LSCC breakdown →