NLRP1

Across TCGA patient cohorts, NLRP1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,208 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NLRP1-associated genes across cancer lineages are CD69, CASS4, and CFH. Each is linked with NLRP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP1-to-partner and partner-to-NLRP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLRP1 versus CD69 in BRCA, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP1→partner) and Y-score (partner→NLRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD69 →	+0.956	+0.399	<.001	<.001	3	4
LUAD	CASS4 →	+0.642	+0.252	<.001	.003	3	4
HNSC	CFH →	+0.829	+0.276	.004	.007	3	4
HNSC	MEFV →	+0.698	+0.303	.001	.007	3	3
HNSC	MS4A6A →	+0.771	+0.395	.008	<.001	3	3
HNSC	ADGRE2 →	+0.471	+0.301	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,208 associations by consensus.

NLRP1 vs CD69 — BRCA

Explore this scatter interactively →