NLRP1

Across TCGA patient cohorts, NLRP1 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, GAPDH, and Caspase-7-cleavedD198. Each is linked with NLRP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP1-to-partner and partner-to-NLRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by NLRP1-low versus NLRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP1→partner) and Y-score (partner→NLRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.389	-2.115	.001	<.001	3	4
COAD	GAPDH →	+0.611	+2.593	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.724	+1.753	.008	.047	3	3
UCEC	TFRC →	+0.451	+1.836	.001	.001	3	3
LUSC	eIF4E →	+0.167	+2.816	.046	.036	3	2
LUAD	4E-BP1_pT70 →	+0.313	+3.016	.002	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

p38-MAPK_pT180_Y182 by NLRP1 expression — UCEC

Explore this box plot interactively →