NLRP1

Across TCGA cell cohorts, NLRP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,726 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NLRP1-associated GO terms across cancer lineages are Cellular response to light stimulus, Positive regulation of canonical NF-kappaB signal transduction, and Cellular response to UV-B. Each is linked with NLRP1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NLRP1-to-partner and partner-to-NLRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to light stimulus grouped by NLRP1-low versus NLRP1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP1→partner) and Y-score (partner→NLRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cellular response to light stimulus →	+0.052	+1.895	.002	.005	3	13
OESOPHAGUS	Positive regulation of canonical NF-kappaB signal transduction →	+0.069	+3.555	<.001	.001	3	12
BONE	Cellular response to UV-B →	+0.215	+2.066	<.001	<.001	3	12
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.169	+3.436	.003	.003	3	11
SKIN	Cellular response to UV →	+0.060	+2.126	<.001	<.001	3	11
OESOPHAGUS	Regulation of post-translational protein modification →	+0.066	+2.580	.001	.006	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,726 associations by consensus.

Cellular response to light stimulus by NLRP1 expression — BONE

Explore this box plot interactively →