NLRC5

Across TCGA patient cohorts, NLRC5 mutation is significantly associated with the RNA expression of many other genes, with 6,119 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRC5-associated genes across cancer lineages are PLD4, GOT1, and GPI. Each is linked with NLRC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both NLRC5-to-partner and partner-to-NLRC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLD4 grouped by NLRC5-low versus NLRC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC5→partner) and Y-score (partner→NLRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLD4 →	-0.327	-1.783	.002	<.001	3	6
HNSC	GOT1 →	+0.629	+3.356	<.001	.005	3	6
UCEC	GPI →	+0.339	+1.595	.002	<.001	3	6
UCEC	DONSON →	+0.403	+4.202	<.001	<.001	3	5
HNSC	STOML2 →	+0.590	+3.204	.003	.009	3	5
HNSC	MELK →	+0.951	+3.482	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,119 associations by consensus.

PLD4 by NLRC5 expression — UCEC

Explore this box plot interactively →