NLRC5

Across TCGA cell cohorts, NLRC5 mutation is significantly associated with the RNA expression of many other genes, with 1,800 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRC5-associated genes across cancer lineages are C1orf189, IDI2, and IZUMO3. Each is linked with NLRC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRC5-to-partner and partner-to-NLRC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by NLRC5-low versus NLRC5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC5→partner) and Y-score (partner→NLRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	C1orf189 →	+0.161	+2.538	<.001	.007	3	3
LUNG_SCLC	IDI2 →	+0.037	+4.459	<.001	.001	3	2
LUNG_SCLC	IZUMO3 →	+0.499	+4.256	<.001	.002	3	2
LARGE_INTESTINE	RBBP8 →	+0.597	+2.158	.002	.004	3	2
LARGE_INTESTINE	ARMC1 →	+0.442	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	DHX15 →	+0.560	+3.257	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,800 associations by consensus.

C1orf189 by NLRC5 expression — CNS

Explore this box plot interactively →