NLRC3

Across TCGA cell cohorts, NLRC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,021 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NLRC3-associated GO terms across cancer lineages are Cytoskeleton-dependent intracellular transport, Regulation of organelle assembly, and Regulation of cilium assembly. Each is linked with NLRC3 in more than 14 cancer types. Because this analysis shows association rather than direction, both NLRC3-to-partner and partner-to-NLRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoskeleton-dependent intracellular transport grouped by NLRC3-low versus NLRC3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC3→partner) and Y-score (partner→NLRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Cytoskeleton-dependent intracellular transport →	+0.050	+0.198	.007	.007	2	15
OESOPHAGUS	Regulation of organelle assembly →	+0.048	+0.299	<.001	<.001	3	14
BREAST	Regulation of cilium assembly →	+0.071	+0.218	<.001	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.102	+0.137	<.001	<.001	3	13
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.114	+0.304	.003	.001	3	13
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.112	+0.294	.002	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,021 associations by consensus.

Cytoskeleton-dependent intracellular transport by NLRC3 expression — LUNG_SCLC

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